GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7923609 | 1 | rs10761723 | chr10:64955581 | NRBF2 | chr10:64893007-64914785:+ | -0.17 | -6.06 | 1.83E-9 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7923609 | 1 | rs10761727 | chr10:64995493 | NRBF2 | chr10:64893007-64914785:+ | -0.16 | -5.89 | 5.31E-9 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7923609 | 1 | rs10761742 | chr10:65085048 | NRBF2 | chr10:64893007-64914785:+ | -0.16 | -6.03 | 2.31E-9 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs10160456 | 1 | rs10767626 | chr11:27306545 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.1 | 4.37E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767628 | chr11:27310871 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.21 | 2.82E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767630 | chr11:27314069 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.11 | 4.25E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767632 | chr11:27318465 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.15 | 3.52E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767633 | chr11:27329725 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.15 | 3.57E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767634 | chr11:27332474 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.23 | 2.49E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767635 | chr11:27333438 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.23 | 2.56E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767636 | chr11:27334061 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.23 | 2.49E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10767637 | chr11:27336082 | LGR4 | chr11:27387510-27494334:- | 0.15 | 4.22 | 2.66E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs1568889 | 1 | rs10767693 | chr11:28093926 | METT5D1 | chr11:28129798-28355054:+ | -0.11 | -3.58 | 0.000357 | Bipolar disorder |
| BRCA | cis | rs10767971 | 1 | rs10767971 | chr11:32895664 | CCDC73 | chr11:32623627-32816187:- | 0.21 | 5.81 | 8.34E-9 | Parkinson's disease (age of onset) |
| BRCA | cis | rs10767971 | 1 | rs10767971 | chr11:32895664 | QSER1 | chr11:32914792-33014862:+ | 0.09 | 3.8 | 0.000154 | Parkinson's disease (age of onset) |